2013年9月27日 星期五

鼬獾狂犬病選讀:

鼬獾狂犬病選讀:
2009年印度製作的人類狂犬病教學紀錄片。Humans with rabies documentary from india 2009

中國東南部的鼬獾狂犬病Rabies in Ferret Badgers, Southeastern China
中國在1994年出現因鼬獾狂犬病感染人類的狂犬病病例。Ferret badger–associated human rabies cases emerged in China in 1994.
http://wwwnc.cdc.gov/eid/article/15/6/08-1485_article.htm
杭州村民捕食野生动物 今年已有五人死于狂犬病http://news.sina.com.cn/c/2003-07-08/09391300011.shtml
在中國東南起源的鼬獾狂犬病及應重視鼬獾狂犬病傳播的潛在來源Ferret badger rabies origin and its revisited importance as potential source of rabies transmission in Southeast China

 
 
結論:Conclusions: 經基因序列及基因族譜資料比對顯示,造成一個獨立地方性的鼬獾狂犬病流行,有可能是起源於中國東南長期狗狂犬病的橫行群襲 (跨物種狗狂犬病變異病毒)Our data suggest ferret badger-associated rabies has likely formed as an independent enzootic originating from dogs during the long-term rabies infestation in southeast China. 鼬獾狂犬病的公衛角色仍不清楚。The eventual role of FB rabies in public health remains unclear. 然而,在相關鼬獾狂犬病疫區,對鼬獾咬傷的處理與鼬獾狂犬病的認識和控制是立即需要的However, management of ferret badger bites, rabies awareness and control in the related regions should be an immediate need.
從中國江西鼬獾分離出狂犬病毒的全部基因組序列Complete Genome Sequence of a Rabies Virus Isolate from a Ferret Badger (Melogale moschata) in Jiangxi, China
http://genomea.asm.org/content/1/3/e00192-13.full
防疫首靠平常定點監測(抽檢-送驗-分析-阻絕-防治)
在美國,每年對大約12萬隻或更多的動物做狂犬病檢測,結果約有6%為狂犬病陽性反應。在陽性動物的種類和範圍中,狂犬病陽檢出性率在家畜<1%,野生動物>10%。
Approximately 120,000 animals or more are tested for rabies each year in the United States, and approximately 6% are found to be rabid. The proportion of positive animals depends largely on the species of animal and ranges from <1% in domestic animals to >10% of wildlife species.
CDC - Diagnosis: In Animals and Humans - Rabies
http://www.cdc.gov/rabies/diagnosis/animals-humans.html
狂犬病的預防成本Cost of Rabies Prevention
雖然在美國,人類感染狂犬病死亡的病例是很罕見的,但美國疾管局估計每年對狂犬病的檢測-預防和控制的相關費用每年均有所提升,每年預算需超過3億美元。Although human rabies deaths are rare, the estimated public health costs associated with disease detection, prevention, and control have risen, exceeding $300 million annually. 這些費用包括寵物-家禽疫苗,動物控制措施,狂犬病實驗室營運計費用,醫療費用,如暴露狂犬病後的(5劑狂犬病疫苗+免疫球蛋白注射)預防(PEP)措施。
These costs include the vaccination of companion animals, animal control programs, maintenance of rabies laboratories, and medical costs, such as those incurred for rabies postexposure prophylaxis (PEP).
這些狂犬病的檢測-預防和控制的相關費用的支出是無法準確的估計。雖然在美國,每年存在暴露狂犬病後的(5劑狂犬病疫苗+免疫球蛋白注射)預防(PEP)措施的疑似病例需求量數量是未知的,預估每年大約為40,000案需暴露狂犬病後的(5劑狂犬病疫苗+免疫球蛋白注射)預防(PEP)措施的疑似狂犬病病例。 Accurate estimates of these expenditures are not available. Although the number of PEPs given in the United States each year is unknown, it is estimated to be about 40,000. 一個超過4週的狂犬病療程:包括5劑的疫苗+免疫球蛋白通常超過1000美元(4萬臺幣)。a course of rabies immune globulin and five doses of vaccine given over a 4-week period typically exceeds $1,000. 依據各地區發生和暴露在狂犬病的不同規模疫情的機率和本質而訂的成本有所差異,光是從超過4週的狂犬病救命療程(5劑狂犬病疫苗+免疫球蛋白注射)的範圍每年預算就有約需100至1億美元的差異.The cost per human life saved from rabies ranges from approximately $10,000 to $100 million, depending on the nature of the exposure and the probability of rabies in a region.
CDC - Cost of Rabies Prevention - Rabies
http://www.cdc.gov/rabies/location/usa/cost.html

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